The most significant role of the drug statins in the reduction of serum lipids has been well recognized in both primary and secondary prevention studies. However, after proven its efficacy statins remain underutilized in numerous settings. Recently, studies are suggesting that statins might positively impact many organs systems and disease states independent of lipid reduction, has appeared and their anti-inflammatory effects have also been investigated. Atorvastatin is one of the most widely prescribed statin in the world. The statin-mediated anti-inflammatory effects in addition to its lipid lowering properties and also reduces the risk for cardiovascular diseases. It is to be highlighted that the drug atorvastatin, has multiple effects on different pathways of the multifactorial etiology of cardiovascular diseases. This is supporting the practice of early introduction of atorvastatin in high-risk patients.